Product Description: 60S ribosomal protein L35, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0015934 | large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.67 | 0.35 |
| Trophozoite | expressed | 1.99 | 0.22 |
| Schizont | expressed | 0.36 | 0.79 |
| Gametocyte | expressed | 1.75 | 0.26 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1124900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.12 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIB4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100532
Most Similar Human Ortholog: P42766
TM-align score: 0.94 | RMSD: 0.98
Seq Identity: 0.49 | Length: 122 / 124
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000136942 | ribosomal protein L35 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 9 | 7 | 5 |
| disruptive | 0 | 8 | 6 | 16 |
| missense | 0 | 7 | 4 | 15 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 17 | 6 | 6 |
| disruptive | 3 | 24 | 12 | 31 |
| missense | 1 | 18 | 11 | 16 |
PlasmoDB Total SNPs: 238
Non-coding: 233 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 124 | Molecular Weight (kDa): 14.748
UniProt ID(s): Q26035, Q8IIB4, Q9U935
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001854 | Ribosomal protein L29/L35 |
| InterPro | IPR036049 | Ribosomal protein L29/L35 superfamily |
| PFam | PF00831 | Ribosomal protein L29/L35 |
| Superfamily | SSF46561 | Ribosomal protein L29/L35 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |