About Gene List

PF3D7_1125000

Genome location: Pf3D7_11_v3:983,393..985,829(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.02 0.99
Trophozoite expressed 0.17 0.88
Schizont expressed 0.18 0.88
Gametocyte expressed 0.28 0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1125000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.945 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIB3

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=6.58) with 7LT5 (Global RMSD=16.87)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139466

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 14 9 17
disruptive 1 25 17 31
missense 1 22 14 26

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 28 8 25
disruptive 4 68 23 68
missense 1 47 22 48

PlasmoDB Total SNPs: 235

Non-coding: 212 | Synonymous: 19 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 290 | Molecular Weight (kDa): 34.708

UniProt ID(s): Q8IIB3

PDB ID(s): None

Isoelectric Point: 9.67

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895