Product Description: ATP synthase F0 subunit b-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | not expressed | 0.27 | 0.82 |
| Schizont | not expressed | 0.10 | 0.93 |
| Gametocyte | not expressed | 0.62 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1125100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.052 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIB2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 30 | 26 | 20 |
| disruptive | 25 | 38 | 24 | 61 |
| missense | 25 | 38 | 23 | 53 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 61 | 17 | 23 |
| disruptive | 39 | 74 | 42 | 119 |
| missense | 38 | 64 | 38 | 88 |
PlasmoDB Total SNPs: 125
Non-coding: 79 | Synonymous: 22 | Nonsynonymous: 24 | Stop Codon: 0
Protein Length: 496 | Molecular Weight (kDa): 59.251
UniProt ID(s): Q8IIB2
PDB ID(s): None
Isoelectric Point: 8.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008688 | ATP synthase, F0 complex, subunit B/MI25 |
| PFam | PF05405 | ATP synthase, F0 complex, subunit B/MI25 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 27594426 | A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential ApicomplexanGenes. | Sidik SM, Huet D, ..., Lourido S | 10.1016/j.cell.2016.08.019 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 30204085 | Identification of cryptic subunits from an apicomplexan ATP synthase | Huet D, Rajendran E, van Dooren GG, Lourido S | 10.7554/eLife.38097 |