PF3D7_1125200

Genome location: Pf3D7_11_v3:988,330..991,296(-)

Genome classification: Core

Function and Localization

Product Description: ubiquitin-like domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.13	0.94
Trophozoite	possibly expressed	0.31	0.81
Schizont	possibly expressed	0.06	0.96
Gametocyte	possibly expressed	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1125200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.161 | MFS: -2.743 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZYV5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146365

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 252

Non-coding: 237 | Synonymous: 13 | Nonsynonymous: 1 | Stop Codon: 1

Protein Information

Protein Length: 238 | Molecular Weight (kDa): 28.254

UniProt ID(s): A0A143ZYV5

PDB ID(s): None

Isoelectric Point: 10.29

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000626	Ubiquitin-like domain
InterPro	IPR029071	Ubiquitin-like domain superfamily
InterPro	IPR040352	Transmembrane and ubiquitin-like domain-containing protein 1/2
PFam	PF00240	Ubiquitin-like domain
Superfamily	SSF54236	Ubiquitin-like domain superfamily