Genome location: Pf3D7_11_v3:1,001,988..1,003,900(-)
Genome classification: Core
Product Description: respiratory chain complex 4 associated protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Component | GO:0045277 | respiratory chain complex IV |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.02 | 0.99 |
| Trophozoite | no data | 0.18 | 0.88 |
| Schizont | no data | 0.25 | 0.83 |
| Gametocyte | no data | 0.23 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1125600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.12 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3G9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 1 | 7 |
| disruptive | 1 | 7 | 5 | 10 |
| missense | 1 | 7 | 5 | 9 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 2 | 11 |
| disruptive | 2 | 16 | 12 | 25 |
| missense | 2 | 12 | 8 | 17 |
PlasmoDB Total SNPs: 100
Non-coding: 96 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 83 | Molecular Weight (kDa): 9.97
UniProt ID(s): C6S3G9
PDB ID(s): None
Isoelectric Point: 10.5
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34155201 | Composition and stage dynamics of mitochondrial complexes in Plasmodiumfalciparum. | Evers F, Cabrera-Orefice A, ..., Kooij TWA | 10.1038/s41467-021-23919-x |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |