About Gene List

PF3D7_1125700

Genome location: Pf3D7_11_v3:1,004,021..1,007,682(-)

Genome classification: Core

Function and Localization

Product Description: kelch domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.41 0.85
Trophozoite possibly expressed 0.10 0.94
Schizont expressed 0.48 0.79
Gametocyte expressed 0.15 0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1125700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.79 | MFS: -2.968 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIA7

"Best" AlphaFill ligand hit: DTU ((2r,3s)-1,4-dimercaptobutane-2,3-diol, Local RMSD=2.76) with 1YWM (Global RMSD=24.90)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119978

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 30 15 33
disruptive 36 65 36 94
missense 25 39 22 67

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 56 33 34
disruptive 54 146 66 160
missense 33 91 47 97

PlasmoDB Total SNPs: 224

Non-coding: 146 | Synonymous: 49 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 669 | Molecular Weight (kDa): 78.076

UniProt ID(s): Q8IIA7

PDB ID(s): None

Isoelectric Point: 6.25

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011043 Galactose oxidase/kelch, beta-propeller
PFam PF13418 N/A
Superfamily SSF50965 Galactose oxidase/kelch, beta-propeller

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104