PF3D7_1125800

Genome location: Pf3D7_11_v3:1,007,693..1,011,537(-)

Genome classification: Core

Function and Localization

Product Description: kelch domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.44	0.85
Trophozoite	possibly expressed	0.04	0.98
Schizont	expressed	0.27	0.90
Gametocyte	not expressed	0.04	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1125800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.254 | #Insertions: 3

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0922500)

Relative Growth Rate: 0.09 ± 0.11
Confidence: 5.72

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IIA6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_154599

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	17	10	28
disruptive	16	51	27	68
missense	8	37	25	58

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	37	14	36
disruptive	28	99	49	97
missense	12	75	43	71

PlasmoDB Total SNPs: 232

Non-coding: 156 | Synonymous: 28 | Nonsynonymous: 44 | Stop Codon: 4

Protein Information

Protein Length: 592 | Molecular Weight (kDa): 67.621

UniProt ID(s): Q8IIA6

PDB ID(s): None

Isoelectric Point: 5.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011043	Galactose oxidase/kelch, beta-propeller
PFam	PF13418	N/A
Superfamily	SSF50965	Galactose oxidase/kelch, beta-propeller

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104