Genome location: Pf3D7_11_v3:1,023,770..1,025,989(-)
Genome classification: Core
Product Description: 40S ribosomal protein S18, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Component | GO:0015935 | small ribosomal subunit |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.33 | 0.44 |
| Trophozoite | expressed | 1.71 | 0.26 |
| Schizont | expressed | 0.39 | 0.76 |
| Gametocyte | not expressed | 0.79 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1126200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.125 | MFS: -2.983 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIA2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100333
Most Similar Human Ortholog: P62269
TM-align score: 0.89 | RMSD: 1.44
Seq Identity: 0.66 | Length: 143 / 156
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000096150 | ribosomal protein S18 |
| ENSG00000223367 | ribosomal protein S18 |
| ENSG00000226225 | ribosomal protein S18 |
| ENSG00000227794 | ribosomal protein S18 |
| ENSG00000231500 | ribosomal protein S18 |
| ENSG00000235650 | ribosomal protein S18 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 1 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 127
Non-coding: 120 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 156 | Molecular Weight (kDa): 17.891
UniProt ID(s): Q8IIA2
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 11.19
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001892 | Ribosomal protein S13 |
| InterPro | IPR010979 | Ribosomal protein S13-like, H2TH |
| InterPro | IPR018269 | Ribosomal protein S13, conserved site |
| PFam | PF00416 | Ribosomal protein S13 |
| Superfamily | SSF46946 | Ribosomal protein S13-like, H2TH |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 37358794 | RNA sequencing reveals the mechanism of FTO in inhibiting inflammation andexcessive proliferation of lipopolysaccharide-induced human glomerular mesangialcells | Zhuang X, Liu T, ..., Gao J | 10.1007/s00210-023-02570-x |