PF3D7_1126300

Genome location: Pf3D7_11_v3:1,026,914..1,029,706(+)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	not expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1126300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -2.879 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZZE4

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.63) with 6JWR (Global RMSD=16.32)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532710

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	24	18	38
disruptive	29	77	49	104
missense	13	67	39	85

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	53	25	36
disruptive	44	167	78	173
missense	21	134	64	121

PlasmoDB Total SNPs: 200

Non-coding: 117 | Synonymous: 32 | Nonsynonymous: 50 | Stop Codon: 1

Protein Information

Protein Length: 617 | Molecular Weight (kDa): 73.529

UniProt ID(s): A0A143ZZE4

PDB ID(s): None

Isoelectric Point: 8.94

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	N/A	N/A
Superfamily	SSF46565	Chaperone J-domain superfamily