Genome location: Pf3D7_11_v3:1,030,509..1,031,799(+)
Genome classification: Core
Product Description: mediator of RNA polymerase II transcription subunit 21, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016592 | mediator complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.13 | 0.93 |
| Trophozoite | expressed | 0.35 | 0.79 |
| Schizont | not expressed | 0.04 | 0.98 |
| Gametocyte | possibly expressed | 0.36 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1126400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.14 | MFS: -2.959 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IIA0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 10 | 3 | 9 |
| disruptive | 1 | 12 | 11 | 23 |
| missense | 1 | 10 | 11 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 20 | 7 | 12 |
| disruptive | 2 | 37 | 30 | 40 |
| missense | 1 | 29 | 22 | 32 |
PlasmoDB Total SNPs: 81
Non-coding: 77 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 181 | Molecular Weight (kDa): 21.719
UniProt ID(s): Q8IIA0
PDB ID(s): None
Isoelectric Point: 4.37
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR037212 | Mediator complex, subunit Med7/Med21-like |
| PFam | N/A | N/A |
| Superfamily | SSF140718 | Mediator complex, subunit Med7/Med21-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 35557691 | Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates withEvolutionarily Novel Subunits. | Iyer UB, Park JE, ..., Featherstone M | 10.1021/acsomega.2c00368 |
| 16758199 | Functional and physical interactions within the middle domain of the yeastmediator | Hallberg M, Hu GZ, ..., Ronne H | 10.1007/s00438-006-0135-7 |
| 16452140 | A functional module of yeast mediator that governs the dynamic range ofheat-shock gene expression | Singh H, Erkine AM, ..., Gross DS | 10.1534/genetics.105.052738 |
| 22377631 | Role of Mediator in regulating Pol II elongation and nucleosome displacement inSaccharomyces cerevisiae | Kremer SB, Kim S, ..., Gross DS | 10.1534/genetics.111.135806 |