About Gene List

PF3D7_1126500

Genome location: Pf3D7_11_v3:1,032,312..1,037,531(+)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.14 0.50
Trophozoite expressed 0.83 0.57
Schizont expressed 0.18 0.89
Gametocyte expressed 0.76 0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1126500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -2.957 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II99

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532854

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 57 30 89
disruptive 47 108 68 170
missense 30 90 62 143

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 123 61 100
disruptive 84 285 143 375
missense 54 223 114 242

PlasmoDB Total SNPs: 210

Non-coding: 62 | Synonymous: 76 | Nonsynonymous: 69 | Stop Codon: 3

Protein Information

Protein Length: 1368 | Molecular Weight (kDa): 163.536

UniProt ID(s): Q8II99

PDB ID(s): None

Isoelectric Point: 6.6

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036322 WD40-repeat-containing domain superfamily
PFam N/A N/A
Superfamily SSF50978 WD40-repeat-containing domain superfamily
Superfamily SSF82171

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104