Genome location: Pf3D7_11_v3:1,040,447..1,048,468(-)
Genome classification: Core
Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005813 | centrosome |
| Component | GO:0005737 | cytoplasm |
| Function | GO:0051959 | dynein light intermediate chain binding |
| Function | GO:0008017 | microtubule binding |
| Process | GO:0031122 | cytoplasmic microtubule organization |
| Process | GO:0030705 | cytoskeleton-dependent intracellular transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.10 | 0.95 |
| Trophozoite | not expressed | 0.13 | 0.93 |
| Schizont | expressed | 1.51 | 0.56 |
| Gametocyte | possibly expressed | 0.95 | 0.53 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1126700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.917 | MFS: -3.049 | #Insertions: 1
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0921700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0921700)
Modification: Disrupted | RMgm-2583
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II97
"Best" AlphaFill ligand hit: BTN (biotin, Local RMSD=10.00) with 2EJ9 (Global RMSD=36.13)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 46 | 26 | 54 |
| disruptive | 15 | 39 | 32 | 105 |
| missense | 14 | 36 | 30 | 97 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 80 | 31 | 69 |
| disruptive | 30 | 111 | 72 | 181 |
| missense | 18 | 92 | 65 | 135 |
PlasmoDB Total SNPs: 493
Non-coding: 446 | Synonymous: 33 | Nonsynonymous: 14 | Stop Codon: 0
Protein Length: 926 | Molecular Weight (kDa): 110.116
UniProt ID(s): Q8II97
PDB ID(s): None
Isoelectric Point: 6.54
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 15556634 | Atg21p is essential for macropexophagy and microautophagy in the yeast Hansenulapolymorpha | Leao-Helder AN, Krikken AM, ..., Kiel JA | 10.1016/j.febslet.2004.10.055 |
| 35443167 | Dimerization-dependent membrane tethering by Atg23 is essential for yeastautophagy | Hawkins WD, Leary KA, ..., Ragusa MJ | 10.1016/j.celrep.2022.110702 |
| 16230342 | Molecular mechanisms and regulation of specific and nonspecific autophagypathways in yeast | Nair U, Klionsky DJ | 10.1074/jbc.R500016200 |
| 28927260 | The Roles of the SNARE Protein Sed5 in Autophagy in Saccharomyces cerevisiae | Zou S, Sun D, Liang Y | 10.14348/molcells.2017.0030 |
| 17700056 | Overexpression of autophagy-related genes inhibits yeast filamentous growth | Ma J, Jin R, ..., Kumar A | 10.4161/auto.4784 |