Genome location: Pf3D7_11_v3:1,049,176..1,052,926(+)
Genome classification: Core
Product Description: alternative splicing factor SR-MG, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0016607 | nuclear speck |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Process | GO:0045292 | mRNA cis splicing, via spliceosome |
| Process | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.05 | 0.98 |
| Trophozoite | expressed | 0.04 | 0.98 |
| Schizont | not expressed | 0.11 | 0.94 |
| Gametocyte | expressed | 1.11 | 0.48 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1126800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.994 | MFS: -2.184 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0921600)
Modification: Tagged | RMgm-4658
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II95
"Best" AlphaFill ligand hit: M2M (1-methoxy-2-(2-methoxyethoxy)ethane, Local RMSD=0.45) with 4ED5 (Global RMSD=3.12)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_107066
Most Similar Human Ortholog: Q6IQ42
TM-align score: 0.71 | RMSD: 2.05
Seq Identity: 0.39 | Length: 59 / 914
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000188529 | serine and arginine rich splicing factor 10 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 37 | 24 | 55 |
| disruptive | 75 | 179 | 83 | 185 |
| missense | 47 | 152 | 70 | 148 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 87 | 47 | 56 |
| disruptive | 123 | 343 | 144 | 343 |
| missense | 77 | 275 | 117 | 221 |
PlasmoDB Total SNPs: 211
Non-coding: 90 | Synonymous: 54 | Nonsynonymous: 66 | Stop Codon: 1
Protein Length: 914 | Molecular Weight (kDa): 108.999
UniProt ID(s): Q8II95
PDB ID(s): None
Isoelectric Point: 10.34
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 31370870 | Alternative splicing is required for stage differentiation in malaria parasites. | Yeoh LM, Goodman CD, ..., Ralph SA | 10.1186/s13059-019-1756-6 |