Genome location: Pf3D7_11_v3:1,052,969..1,054,388(-)
Genome classification: Core
Product Description: small nuclear ribonucleoprotein F, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005685 | U1 snRNP |
| Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Component | GO:0005682 | U5 snRNP |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.07 | 0.95 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.04 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1126900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.12 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0921500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0921500)
Modification: Disrupted | RMgm-2581
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II94
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102196
Most Similar Human Ortholog: P62306
TM-align score: 0.91 | RMSD: 1.21
Seq Identity: 0.58 | Length: 83 / 86
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000139343 | small nuclear ribonucleoprotein polypeptide F |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 7 | 2 | 5 |
| disruptive | 1 | 1 | 1 | 8 |
| missense | 1 | 1 | 1 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 10 | 5 | 5 |
| disruptive | 1 | 10 | 7 | 25 |
| missense | 1 | 7 | 5 | 18 |
PlasmoDB Total SNPs: 116
Non-coding: 110 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 86 | Molecular Weight (kDa): 9.89
UniProt ID(s): Q8II94
PDB ID(s): None
Isoelectric Point: 8.94
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001163 | LSM domain, eukaryotic/archaea-type |
| InterPro | IPR010920 | LSM domain superfamily |
| InterPro | IPR016487 | Sm-like protein Lsm6/SmF |
| InterPro | IPR034100 | Small nuclear ribonucleoprotein F |
| PFam | PF01423 | LSM domain, eukaryotic/archaea-type |
| Superfamily | SSF50182 | LSM domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |