About Gene List

PF3D7_1127000

Genome location: Pf3D7_11_v3:1,055,701..1,058,777(-)

Genome classification: Core

Function and Localization

Product Description: protein phosphatase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020020 food vacuole
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.27 0.86
Trophozoite possibly expressed 0.43 0.74
Schizont not expressed 0.05 0.97
Gametocyte not expressed 0.09 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1127000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.05 | #Insertions: 4

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0921400)

  • Relative Growth Rate: 0.82 ± 0.14
  • Confidence: 5.39

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0921400)

Modification: Disrupted | RMgm-2580

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II93

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.1.3.16 protein-serine/threonine phosphatase ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119689

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 17 2 12
disruptive 10 17 10 28
missense 10 16 10 27

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 26 6 17
disruptive 13 49 26 64
missense 13 36 24 43

PlasmoDB Total SNPs: 186

Non-coding: 168 | Synonymous: 4 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 287 | Molecular Weight (kDa): 34.461

UniProt ID(s): Q8II93

PDB ID(s): None

Isoelectric Point: 7.9

Protein Domain Annotations:

Source Family ID Description
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR029021 Protein-tyrosine phosphatase-like
PFam N/A N/A
Superfamily SSF52799 Protein-tyrosine phosphatase-like

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
21136929 Food vacuole proteome of the malarial parasite Plasmodium falciparum. Lamarque M, Tastet C, ..., Dubremetz JF 10.1002/prca.200700112
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596