PF3D7_1127400

Genome location: Pf3D7_11_v3:1,064,993..1,067,053(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MMERKMKKNKFILFFFFLFTIKTVHI

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1127400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.123 | MFS: -3.027 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0921000)

• Relative Growth Rate: 0.11 ± 0.09
• Confidence: 6.15

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II89

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532802

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 122

Non-coding: 117 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 2

Protein Information

Protein Length: 159 | Molecular Weight (kDa): 19.472

UniProt ID(s): Q8II89

PDB ID(s): None

Isoelectric Point: 10.72

Protein Domain Annotations: