PF3D7_1127600

Genome location: Pf3D7_11_v3:1,071,718..1,074,209(+)

Genome classification: Core

Function and Localization

Product Description: CRAL/TRIO domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1127600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.178 | MFS: -3.244 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1125200)

• Relative Growth Rate: 0.06 ± 0.09
• Confidence: 6.16

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II87

"Best" AlphaFill ligand hit: 6PL ((4s,7r)-4-hydroxy-n,n,n-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide, Local RMSD=8.17) with 3B7Q (Global RMSD=6.38)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111807

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 144

Non-coding: 139 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 297 | Molecular Weight (kDa): 34.967

UniProt ID(s): Q8II87

PDB ID(s): None

Isoelectric Point: 8.2

Protein Domain Annotations: