PF3D7_1127700

Genome location: Pf3D7_11_v3:1,074,626..1,076,405(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.23	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1127700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.261 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II86

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532921

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	19	14	27
disruptive	10	67	41	107
missense	10	53	34	90

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	45	13	29
disruptive	22	165	71	162
missense	15	130	58	103

PlasmoDB Total SNPs: 101

Non-coding: 38 | Synonymous: 31 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 447 | Molecular Weight (kDa): 53.074

UniProt ID(s): Q8II86

PDB ID(s): None

Isoelectric Point: 5.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A