About Gene List

PF3D7_1127800

Genome location: Pf3D7_11_v3:1,076,956..1,082,092(-)

Genome classification: Core

Function and Localization

Product Description: TFIIS central domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.99 0.58
Trophozoite not expressed 1.13 0.45
Schizont not expressed 0.48 0.73
Gametocyte not expressed 0.78 0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1127800

Resistome Missense Mutations: V204E

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.198 | MFS: -2.706 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II85

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=2.33) with 5OXF (Global RMSD=18.16)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532642

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 40 33 69
disruptive 51 191 105 255
missense 32 162 95 216

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 112 41 86
disruptive 119 466 182 448
missense 60 350 145 273

PlasmoDB Total SNPs: 206

Non-coding: 70 | Synonymous: 79 | Nonsynonymous: 57 | Stop Codon: 0

Protein Information

Protein Length: 1420 | Molecular Weight (kDa): 168.743

UniProt ID(s): Q8II85

PDB ID(s): None

Isoelectric Point: 8.67

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036575 Transcription elongation factor S-II, central domain superfamily
InterPro IPR039715 Zinc finger CCHC domain-containing protein 10
PFam N/A N/A
Superfamily SSF46942 Transcription elongation factor S-II, central domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108