PF3D7_1127900

Genome location: Pf3D7_11_v3:1,083,321..1,086,048(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.27	0.88
Trophozoite	possibly expressed	0.09	0.95
Schizont	expressed	0.28	0.86
Gametocyte	expressed	0.62	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1127900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -2.962 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II84

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532574

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	15	13	28
disruptive	6	30	18	51
missense	6	26	15	47

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	43	16	33
disruptive	13	71	52	95
missense	10	62	46	65

PlasmoDB Total SNPs: 102

Non-coding: 87 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 409 | Molecular Weight (kDa): 48.257

UniProt ID(s): Q8II84

PDB ID(s): None

Isoelectric Point: 4.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104