About Gene List

PF3D7_1128000

Genome location: Pf3D7_11_v3:1,086,660..1,093,283(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed nd nd
Trophozoite expressed nd nd
Schizont expressed nd nd
Gametocyte expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1128000.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.158 | MFS: -2.838 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II83

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533192

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 21 74 48 105
disruptive 80 253 118 325
missense 51 201 101 270

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 33 147 69 124
disruptive 150 475 201 442
missense 86 383 172 311

PlasmoDB Total SNPs: 256

Non-coding: 96 | Synonymous: 95 | Nonsynonymous: 63 | Stop Codon: 2

Protein Information

Protein Length: 1789 | Molecular Weight (kDa): 212.865

UniProt ID(s): Q8II83

PDB ID(s): None

Isoelectric Point: 6.12

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104