PF3D7_1128100

Genome location: Pf3D7_11_v3:1,094,357..1,096,486(-)

Genome classification: Core

Function and Localization

Product Description: prefoldin subunit 5, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0016272	prefoldin complex
Process	GO:0006355	regulation of transcription, DNA-templated

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.33	0.84
Trophozoite	expressed	1.07	0.45
Schizont	expressed	0.18	0.89
Gametocyte	expressed	1.01	0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1128100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.205 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0920100)

Relative Growth Rate: 0.75 ± 0.10
Confidence: 6.01

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0920100)

Modification: Disrupted | RMgm-2575

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II82

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101532

Most Similar Human Ortholog: F8VQZ2

TM-align score: 0.86 | RMSD: 0.80

Seq Identity: 0.19 | Length: 37 / 248

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000123349	prefoldin subunit 5

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	17	6	12
disruptive	4	9	6	30
missense	4	9	5	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	25	9	21
disruptive	6	33	19	59
missense	5	23	15	42

PlasmoDB Total SNPs: 98

Non-coding: 89 | Synonymous: 3 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 248 | Molecular Weight (kDa): 29.141

UniProt ID(s): Q8II82

PDB ID(s): None

Isoelectric Point: 5.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004127	Prefoldin alpha-like
InterPro	IPR011599	Prefoldin alpha subunit, archaea-type
PFam	PF02996	Prefoldin alpha-like
Superfamily	SSF46579	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104