Genome location: Pf3D7_11_v3:1,096,720..1,097,745(+)
Genome classification: Core
Product Description: multiprotein-bridging factor 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005634 | nucleus |
| Function | GO:0003713 | transcription coactivator activity |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.29 | 0.85 |
| Trophozoite | expressed | 0.46 | 0.72 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | expressed | 0.43 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1128200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.176 | MFS: -2.575 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II81
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102239
Most Similar Human Ortholog: O60869
TM-align score: 0.76 | RMSD: 2.51
Seq Identity: 0.39 | Length: 122 / 136
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000107223 | endothelial differentiation related factor 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 3 | 7 | 3 |
| disruptive | 1 | 2 | 5 | 12 |
| missense | 1 | 2 | 5 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 14 | 4 | 6 |
| disruptive | 1 | 18 | 14 | 29 |
| missense | 1 | 10 | 13 | 19 |
PlasmoDB Total SNPs: 43
Non-coding: 36 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 1
Protein Length: 136 | Molecular Weight (kDa): 15.525
UniProt ID(s): Q8II81
PDB ID(s): None
Isoelectric Point: 10.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001387 | Cro/C1-type helix-turn-helix domain |
| InterPro | IPR010982 | Lambda repressor-like, DNA-binding domain superfamily |
| InterPro | IPR013729 | Multiprotein bridging factor 1, N-terminal |
| PFam | PF01381 | Cro/C1-type helix-turn-helix domain |
| PFam | PF08523 | Multiprotein bridging factor 1, N-terminal |
| Superfamily | SSF47413 | Lambda repressor-like, DNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 32729986 | Newly identified genes contribute to vanillin tolerance in Saccharomycescerevisiae | Liang Z, Wang X, ..., Shen Y | 10.1111/1751-7915.13643 |
| 34301255 | Proteomic analysis revealed the roles of YRR1 deletion in enhancing the vanillinresistance of Saccharomyces cerevisiae | Cao W, Zhao W, ..., Bao X | 10.1186/s12934-021-01633-z |