Genome location: Pf3D7_11_v3:1,110,057..1,112,485(-)
Genome classification: Core
Product Description: CCR4-NOT transcription complex subunit 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030014 | CCR4-NOT complex |
| Component | GO:0030015 | CCR4-NOT core complex |
| Component | GO:0000932 | P-body |
| Function | GO:0004535 | poly(A)-specific ribonuclease activity |
| Process | GO:0017148 | negative regulation of translation |
| Process | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.07 | 0.96 |
| Schizont | not expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 1.12 | 0.44 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1128600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.9 | #Insertions: 4
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II77
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101639
Most Similar Human Ortholog: H0YHT6
TM-align score: 0.76 | RMSD: 2.38
Seq Identity: 0.29 | Length: 94 / 559
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000111596 | CCR4-NOT transcription complex subunit 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 23 | 16 | 43 |
| disruptive | 8 | 72 | 45 | 113 |
| missense | 7 | 66 | 42 | 102 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 51 | 30 | 50 |
| disruptive | 25 | 172 | 81 | 148 |
| missense | 15 | 149 | 70 | 116 |
PlasmoDB Total SNPs: 163
Non-coding: 104 | Synonymous: 36 | Nonsynonymous: 23 | Stop Codon: 0
Protein Length: 559 | Molecular Weight (kDa): 65.782
UniProt ID(s): Q8II77
PDB ID(s): None
Isoelectric Point: 5.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007282 | NOT2/NOT3/NOT5, C-terminal |
| InterPro | IPR040168 | Not2/Not3/Not5 |
| PFam | PF04153 | NOT2/NOT3/NOT5, C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30703164 | Plasmodium male gametocyte development and transmission are critically regulatedby the two putative deadenylases of the CAF1/CCR4/NOT complex. | Hart KJ, Oberstaller J, ..., Lindner SE | 10.1371/journal.ppat.1007164 |
| 25914052 | Architecture of the ubiquitylation module of the yeast Ccr4-Not complex | Bhaskar V, Basquin J, Conti E | 10.1016/j.str.2015.03.011 |
| 24121231 | Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeastCcr4-Not complex | Bhaskar V, Roudko V, ..., Conti E | 10.1038/nsmb.2686 |
| 24427169 | The CAF1-NOT complex of trypanosomes | Erben E, Chakraborty C, Clayton C | 10.3389/fgene.2013.00299 |