About Gene List

PF3D7_1128900

Genome location: Pf3D7_11_v3:1,117,049..1,120,693(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite possibly expressed 0.06 0.96
Schizont expressed 0.89 0.54
Gametocyte expressed 0.32 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1128900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -2.893 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0919400)

  • Relative Growth Rate: 0.09 ± 0.12
  • Confidence: 5.58

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZYW1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134723

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 33 12 39
disruptive 11 35 21 67
missense 11 35 21 58

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 59 28 45
disruptive 15 103 45 155
missense 15 84 34 99

PlasmoDB Total SNPs: 273

Non-coding: 227 | Synonymous: 36 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 622 | Molecular Weight (kDa): 73.854

UniProt ID(s): A0A143ZYW1

PDB ID(s): None

Isoelectric Point: 8.4

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
29269729 A conserved ankyrin repeat-containing protein regulates conoid stability,motility and cell invasion in Toxoplasma gondii. Long S, Anthony B, Drewry LL, Sibley LD 10.1038/s41467-017-02341-2