Genome location: Pf3D7_11_v3:1,124,682..1,128,048(+)
Genome classification: Core
Product Description: parasitophorous vacuolar protein 1
SignalP Peptide: MIKIILASFLFFFYFSSSIYG
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0020020 | food vacuole |
| Component | GO:0020026 | merozoite dense granule |
| Component | GO:0005634 | nucleus |
| Component | GO:0032991 | protein-containing complex |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.62 | 0.34 |
| Trophozoite | expressed | 1.07 | 0.46 |
| Schizont | expressed | 0.46 | 0.71 |
| Gametocyte | expressed | 0.87 | 0.53 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1129100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.111 | #Insertions: 2
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0919100)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0919100)
Modification: Disrupted | RMgm-4536
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II72
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 27 | 13 | 26 |
| disruptive | 29 | 45 | 31 | 96 |
| missense | 22 | 34 | 25 | 70 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 48 | 20 | 39 |
| disruptive | 39 | 100 | 80 | 156 |
| missense | 26 | 74 | 60 | 86 |
PlasmoDB Total SNPs: 183
Non-coding: 139 | Synonymous: 24 | Nonsynonymous: 20 | Stop Codon: 0
Protein Length: 452 | Molecular Weight (kDa): 51.951
UniProt ID(s): Q8II72
PDB ID(s): None
Isoelectric Point: 4.71
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR021689 | Protein of unknown function DUF3271 |
| PFam | PF11675 | Protein of unknown function DUF3271 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 21483790 | Genetic evidence strongly support an essential role for PfPV1 inintra-erythrocytic growth of P. falciparum. | Chu T, Lingelbach K, Przyborski JM | 10.1371/journal.pone.0018396 |
| 28691708 | An exported protein-interacting complex involved in the trafficking of virulencedeterminants in Plasmodium-infected erythrocytes. | Batinovic S, McHugh E, ..., Tilley L | 10.1038/ncomms16044 |
| 29487358 | PV1, a novel Plasmodium falciparum merozoite dense granule protein, interactswith exported protein in infected erythrocytes. | Morita M, Nagaoka H, ..., Takashima E | 10.1038/s41598-018-22026-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |