PF3D7_1129300

Genome location: Pf3D7_11_v3:1,131,284..1,137,072(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.18	0.91
Trophozoite	not expressed	0.15	0.91
Schizont	expressed	1.53	0.37
Gametocyte	not expressed	0.16	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1129300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.027 | #Insertions: 8

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0918900)

Modification: Disrupted | RMgm-2568

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II70

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=0.64) with 3UM6 (Global RMSD=48.25)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533452

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	88	44	139
disruptive	66	217	142	346
missense	46	200	134	314

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	176	93	141
disruptive	120	482	204	465
missense	76	428	192	383

PlasmoDB Total SNPs: 177

Non-coding: 47 | Synonymous: 64 | Nonsynonymous: 64 | Stop Codon: 2

Protein Information

Protein Length: 1846 | Molecular Weight (kDa): 221.709

UniProt ID(s): Q8II70

PDB ID(s): None

Isoelectric Point: 9.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	N/A	N/A
Superfamily	SSF53474	Alpha/Beta hydrolase fold