About Gene List

PF3D7_1129900 (MFR5)

Genome location: Pf3D7_11_v3:1,155,616..1,158,343(+)

Genome classification: Core

Function and Localization

Product Description: major facilitator superfamily-related transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 12

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005886 plasma membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.13 0.93
Trophozoite expressed 0.29 0.83
Schizont expressed 0.07 0.95
Gametocyte expressed 0.41 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1129900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.042 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0918300)

Modification: Disrupted | RMgm-1368

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II64

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_166402

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 29 14 47
disruptive 13 18 13 49
missense 13 18 13 43

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 66 29 33
disruptive 18 57 56 122
missense 16 45 45 77

PlasmoDB Total SNPs: 98

Non-coding: 76 | Synonymous: 10 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 609 | Molecular Weight (kDa): 70.139

UniProt ID(s): Q8II64

PDB ID(s): None

Isoelectric Point: 8.02

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036259 MFS transporter superfamily
PFam N/A N/A
Superfamily SSF103473 MFS transporter superfamily

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
34756057 Characterization of Apicomplexan Amino Acid Transporters (ApiATs) in the MalariaParasite Plasmodium falciparum. Wichers JS, van Gelder C, ..., Bachmann A 10.1128/mSphere.00743-21