Genome location: Pf3D7_11_v3:1,158,440..1,162,440(-)
Genome classification: Core
Product Description: phosphoacetylglucosamine mutase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.4.2.10 (Phosphoglucosamine mutase);5.4.2.3 (Phosphoacetylglucosamine mutase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0004610 | phosphoacetylglucosamine mutase activity |
| Process | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process |
| Process | GO:0006041 | glucosamine metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.30 | 0.86 |
| Trophozoite | expressed | 0.78 | 0.59 |
| Schizont | expressed | 0.16 | 0.90 |
| Gametocyte | expressed | 0.51 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1130000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.167 | MFS: -2.855 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0918200)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0918200)
Modification: Disrupted | RMgm-4610
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II63
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.4.2.10 | phosphoglucosamine mutase | EDTA |
| 5.4.2.3 | phosphoacetylglucosamine mutase | D-glucose 6-phosphateD-glucose 1-phosphate2-acetamido-1,5-anhydro-2-deoxy-D-glucitol2-acetamido-2-deoxy-6-O-sulfo-D-glucopyranose2-acetamido-1,5-anhydro-2-deoxy-6-O-sulfo-D-glucitol2-acetamido-1,5-anhydro-2,6-dideoxy-6-sulfo-D-glucitol2-acetamido-1,5-anhydro-2-deoxy-6-O-phosphono-D-glucitol2-acetamido-1,5-anhydro-2,6-dideoxy-6-phosphono-D-glucitol2-acetamido-1,5-anhydro-2,6-dideoxy-6-(sulfoamino)-D-glucitol2-acetamido-1,5-anhydro-2,6,7-trideoxy-7-phosphono-D-gluco-heptitol2-acetamido-2-deoxy-N-phosphono-6-O-phosphono-D-glucopyranosylamine2,5:4,8-dianhydro-1,3-dideoxy-9-O-phosphono-D-erythro-L-gulo-nonitol... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102413
Most Similar Human Ortholog: D6RCQ8
TM-align score: 0.90 | RMSD: 1.76
Seq Identity: 0.24 | Length: 146 / 940
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000013375 | phosphoglucomutase 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 52 | 24 | 54 |
| disruptive | 54 | 184 | 94 | 190 |
| missense | 29 | 129 | 69 | 131 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 90 | 39 | 51 |
| disruptive | 106 | 309 | 146 | 235 |
| missense | 57 | 212 | 107 | 146 |
PlasmoDB Total SNPs: 230
Non-coding: 114 | Synonymous: 48 | Nonsynonymous: 68 | Stop Codon: 0
Protein Length: 940 | Molecular Weight (kDa): 111.658
UniProt ID(s): Q8II63
PDB ID(s): None
Isoelectric Point: 7.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005843 | Alpha-D-phosphohexomutase, C-terminal |
| InterPro | IPR005844 | Alpha-D-phosphohexomutase, alpha/beta/alpha domain I |
| InterPro | IPR016055 | Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III |
| InterPro | IPR016066 | Alpha-D-phosphohexomutase, conserved site |
| InterPro | IPR036900 | Alpha-D-phosphohexomutase, C-terminal domain superfamily |
| PFam | PF00408 | Alpha-D-phosphohexomutase, C-terminal |
| PFam | PF02878 | Alpha-D-phosphohexomutase, alpha/beta/alpha domain I |
| Superfamily | SSF53738 | Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III |
| Superfamily | SSF55957 | Alpha-D-phosphohexomutase, C-terminal domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 22676716 | Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted byphosphomannomutase and phospho-N-acetylglucosamine mutase | Bandini G, Marino K, ..., Ferguson MA | 10.1111/j.1365-2958.2012.08124.x |