Genome location: Pf3D7_11_v3:1,163,768..1,167,334(+)
Genome classification: Core
Product Description: 60S ribosomal protein P0
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005622 | intracellular |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0070180 | large ribosomal subunit rRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0002181 | cytoplasmic translation |
| Process | GO:0000027 | ribosomal large subunit assembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.55 | 0.40 |
| Trophozoite | expressed | 2.12 | 0.20 |
| Schizont | expressed | 0.58 | 0.68 |
| Gametocyte | expressed | 1.11 | 0.44 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1130200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.208 | MFS: -2.596 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_0919700)
Modification: Tagged | RMgm-1561
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II61
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100781
Most Similar Human Ortholog: F8VU65
TM-align score: 0.93 | RMSD: 1.76
Seq Identity: 0.49 | Length: 247 / 316
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000089157 | ribosomal protein lateral stalk subunit P0 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 17 | 9 | 29 |
| disruptive | 0 | 17 | 9 | 27 |
| missense | 0 | 13 | 9 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 53 | 11 | 23 |
| disruptive | 5 | 38 | 21 | 45 |
| missense | 1 | 29 | 18 | 31 |
PlasmoDB Total SNPs: 220
Non-coding: 214 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 316 | Molecular Weight (kDa): 34.968
UniProt ID(s): Q07477, Q703U6, Q705J5, Q8II61
PDB ID(s): None
Isoelectric Point: 6.66
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001790 | Ribosomal protein L10P |
| InterPro | IPR030670 | 60S acidic ribosomal protein P0 |
| InterPro | IPR040637 | 60S ribosomal protein L10P, insertion domain |
| InterPro | IPR043141 | Ribosomal protein L10-like domain superfamily |
| PFam | PF00428 | Ribosomal protein L10P |
| PFam | PF00466 | 60S ribosomal protein L10P, insertion domain |
| PFam | PF17777 | |
| Superfamily | SSF160369 | Ribosomal protein L10-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21278348 | Human cord blood CD4+CD25hi regulatory T cells suppress prenatally acquired Tcell responses to Plasmodium falciparum antigens. | Mackroth MS, Malhotra I, ..., King CL | 10.4049/jimmunol.1001188 |
| 25450178 | In vivo formation of Plasmodium falciparum ribosomal stalk - a unique mode ofassembly without stable heterodimeric intermediates. | Wawiorka L, Krokowski D, ..., Tchorzewski M | 10.1016/j.bbagen.2014.10.015 |
| 27503796 | Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. | Siau A, Huang X, ..., Preiser PR | 10.1038/srep31055 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 14636674 | Translocation of ribosomal protein P0 onto the Toxoplasma gondii tachyzoitesurface | Sehgal A, Kumar N, Carruthers VB, Sharma S | 10.1016/s0020-7519(03)00267-4 |
| 15322057 | The P domain of the P0 protein of Plasmodium falciparum protects againstchallenge with malaria parasites | Rajeshwari K, Patel K, ..., Sharma S | 10.1128/IAI.72.9.5515-5521.2004 |
| 11683400 | Sera from lupus patients inhibit growth of P. falciparum in culture | Singh S, Chatterjee S, ..., Sharma S | 10.1080/08916934.2002.11873702 |
| 10858250 | Antibodies against ribosomal phosphoprotein P0 of Plasmodium falciparum protectmice against challenge with Plasmodium yoelii | Chatterjee S, Singh S, ..., Sharma S | 10.1128/IAI.68.7.4312-4318.2000 |
| 15908375 | Distinct Th1- and Th2-Type prenatal cytokine responses to Plasmodium falciparumerythrocyte invasion ligands | Malhotra I, Mungai P, ..., King CL | 10.1128/IAI.73.6.3462-3470.2005 |
| 10779592 | Characterization of domains of the phosphoriboprotein P0 of Plasmodiumfalciparum | Chatterjee S, Singh S, ..., Sharma S | 10.1016/s0166-6851(99)00226-1 |
| 16099608 | Functional complementation of yeast ribosomal P0 protein with Plasmodiumfalciparum P0 | Aruna K, Chakraborty T, ..., Sharma S | 10.1016/j.gene.2005.04.007 |
| 22315513 | Plasmodium riboprotein PfP0 induces a deviant humoral immune response in Balb/cmice | Pathak S, Rajeshwari K, ..., Sharma S | 10.1155/2012/695843 |
| 19768630 | Fine mapping of Plasmodium falciparum ribosomal phosphoprotein PfP0 revealedsequences with highly specific binding activity to human red blood cells | Arevalo-Pinzon G, Curtidor H, ..., Patarroyo ME | 10.1007/s00109-009-0533-5 |