PF3D7_1130500 (COG2)

Genome location: Pf3D7_11_v3:1,171,260..1,176,260(+)

Genome classification: Core

Function and Localization

Product Description: conserved oligomeric Golgi complex subunit 2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0017119	Golgi transport complex
Process	GO:0007030	Golgi organization
Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport
Process	GO:0006891	intra-Golgi vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	expressed	0.55	0.68
Schizont	expressed	0.49	0.70
Gametocyte	not expressed	0.48	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1130500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.024 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II59

"Best" AlphaFill ligand hit: CHT (choline ion, Local RMSD=0.59) with 3C5I (Global RMSD=19.14)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532707

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	38	21	60
disruptive	14	110	69	160
missense	13	108	68	147

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	69	38	70
disruptive	44	228	124	222
missense	31	208	108	180

PlasmoDB Total SNPs: 319

Non-coding: 271 | Synonymous: 31 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 985 | Molecular Weight (kDa): 118.332

UniProt ID(s): Q8II59

PDB ID(s): None

Isoelectric Point: 9.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009316	COG complex component, COG2
InterPro	IPR024602	Conserved oligomeric Golgi complex, subunit 2, N-terminal
InterPro	IPR024603	COG complex component, COG2, C-terminal
PFam	PF06148	Conserved oligomeric Golgi complex, subunit 2, N-terminal
PFam	PF12022	COG complex component, COG2, C-terminal
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104