Genome location: Pf3D7_11_v3:1,179,639..1,185,871(-)
Genome classification: Core
Product Description: structural maintenance of chromosomes protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0008278 | cohesin complex |
| Component | GO:0034990 | nuclear mitotic cohesin complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0003690 | double-stranded DNA binding |
| Function | GO:0003680 | minor groove of adenine-thymine-rich DNA binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0000070 | mitotic sister chromatid segregation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.16 | 0.93 |
| Trophozoite | expressed | 1.25 | 0.41 |
| Schizont | expressed | 0.40 | 0.78 |
| Gametocyte | expressed | 1.14 | 0.44 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1130700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.133 | MFS: -3.279 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0917500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II57
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.08) with 5ZXD (Global RMSD=5.96)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101499
Most Similar Human Ortholog: V9GYN9
TM-align score: 0.67 | RMSD: 2.34
Seq Identity: 0.47 | Length: 49 / 1818
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000072501 | structural maintenance of chromosomes 1A |
| ENSG00000077935 | structural maintenance of chromosomes 1B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 90 | 57 | 101 |
| disruptive | 118 | 228 | 115 | 274 |
| missense | 53 | 154 | 92 | 208 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 35 | 154 | 78 | 115 |
| disruptive | 171 | 424 | 181 | 391 |
| missense | 75 | 297 | 144 | 280 |
PlasmoDB Total SNPs: 200
Non-coding: 42 | Synonymous: 78 | Nonsynonymous: 80 | Stop Codon: 0
Protein Length: 1818 | Molecular Weight (kDa): 214.676
UniProt ID(s): Q8II57
PDB ID(s): None
Isoelectric Point: 7.48
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003395 | RecF/RecN/SMC, N-terminal |
| InterPro | IPR010935 | SMCs flexible hinge |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036277 | SMCs flexible hinge superfamily |
| PFam | PF02463 | RecF/RecN/SMC, N-terminal |
| PFam | PF06470 | SMCs flexible hinge |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF75553 | SMCs flexible hinge superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32017676 | The chromatin bound proteome of the human malaria parasite | Batugedara G, Lu XM, ..., Le Roch KG | 10.1099/mgen.0.000327 |