PF3D7_1130800

Genome location: Pf3D7_11_v3:1,187,604..1,189,562(+)

Genome classification: Core

Function and Localization

Product Description: armadillo repeat protein PF16, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	possibly expressed	0.01	0.99
Gametocyte	expressed	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1130800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.957 | MFS: -1.495 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0917400)

Modification: Tagged | RMgm-589

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II56

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104236

Most Similar Human Ortholog: A0A0A0MRT8

TM-align score: 0.92 | RMSD: 2.46

Seq Identity: 0.36 | Length: 479 / 507

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000077327	sperm associated antigen 6

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	34	16	34
disruptive	8	16	8	50
missense	8	16	8	47

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	62	27	30
disruptive	13	49	46	106
missense	12	38	41	71

PlasmoDB Total SNPs: 65

Non-coding: 39 | Synonymous: 21 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 507 | Molecular Weight (kDa): 58.116

UniProt ID(s): Q8II56

PDB ID(s): None

Isoelectric Point: 7.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000225	Armadillo
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR019538	26S proteasome non-ATPase regulatory subunit 5
PFam	PF10508	26S proteasome non-ATPase regulatory subunit 5
Superfamily	SSF48371	Armadillo-type fold