About Gene List

PF3D7_1130900

Genome location: Pf3D7_11_v3:1,190,118..1,194,394(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.98
Trophozoite possibly expressed 0.31 0.82
Schizont not expressed 0.05 0.97
Gametocyte possibly expressed 0.58 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1130900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.999 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II55

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533210

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 15 50 37 92
disruptive 47 182 114 251
missense 33 166 109 238

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 111 51 112
disruptive 95 402 173 341
missense 59 347 154 261

PlasmoDB Total SNPs: 90

Non-coding: 4 | Synonymous: 47 | Nonsynonymous: 39 | Stop Codon: 0

Protein Information

Protein Length: 1352 | Molecular Weight (kDa): 165.115

UniProt ID(s): Q8II55

PDB ID(s): None

Isoelectric Point: 9.61

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094