PF3D7_1131000

Genome location: Pf3D7_11_v3:1,193,687..1,195,036(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein s1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	expressed	0.31	0.81
Schizont	expressed	0.03	0.98
Gametocyte	expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1131000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.091 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II54

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532370

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	9	5	11
disruptive	44	70	18	49
missense	16	31	9	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	19	5	7
disruptive	67	95	31	82
missense	26	43	13	40

PlasmoDB Total SNPs: 142

Non-coding: 55 | Synonymous: 17 | Nonsynonymous: 70 | Stop Codon: 0

Protein Information

Protein Length: 170 | Molecular Weight (kDa): 19.992

UniProt ID(s): Q8II54

PDB ID(s): None

Isoelectric Point: 4.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR035979	RNA-binding domain superfamily
PFam	N/A	N/A
Superfamily	SSF54928	RNA-binding domain superfamily