Genome location: Pf3D7_11_v3:1,195,469..1,198,419(-)
Genome classification: Core
Product Description: serpentine receptor 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 7
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0012505 | endomembrane system |
| Component | GO:0016020 | membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.15 | 0.93 |
| Trophozoite | expressed | 0.67 | 0.65 |
| Schizont | expressed | 1.14 | 0.49 |
| Gametocyte | expressed | 0.83 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1131100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.547 | MFS: -2.479 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0917100)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0918700)
Modification: Disrupted | RMgm-4757
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II53
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 33 | 28 | 17 | 41 |
| disruptive | 92 | 143 | 77 | 146 |
| missense | 33 | 99 | 58 | 110 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 41 | 60 | 26 | 57 |
| disruptive | 127 | 278 | 113 | 238 |
| missense | 49 | 188 | 89 | 147 |
PlasmoDB Total SNPs: 148
Non-coding: 43 | Synonymous: 66 | Nonsynonymous: 39 | Stop Codon: 0
Protein Length: 773 | Molecular Weight (kDa): 94.428
UniProt ID(s): Q8II53
PDB ID(s): None
Isoelectric Point: 8.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008429 | Cleft lip and palate transmembrane 1 |
| InterPro | IPR030434 | Cleft lip and palate transmembrane protein 1-like protein |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 38075902 | The splicing factor SR2 is an important virulence factor of Toxoplasma gondii | Wu XJ, Gao J, ..., Zhu XQ | 10.3389/fmicb.2023.1302512 |