About Gene List

PF3D7_1131200

Genome location: Pf3D7_11_v3:1,199,053..1,202,149(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.07 0.97
Trophozoite possibly expressed 0.38 0.78
Schizont expressed 0.48 0.72
Gametocyte expressed 0.95 0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1131200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.989 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II52

"Best" AlphaFill ligand hit: LVV (4-[(4-methylphenyl)methyl]-1,4-thiazinane 1,1-dioxide, Local RMSD=0.31) with 5S66 (Global RMSD=28.22)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533550

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 9 15 26
disruptive 5 26 17 37
missense 5 24 16 31

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 28 18 35
disruptive 17 67 27 98
missense 10 49 21 65

PlasmoDB Total SNPs: 246

Non-coding: 203 | Synonymous: 31 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 381 | Molecular Weight (kDa): 46.558

UniProt ID(s): Q8II52

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104