PF3D7_1131300

Genome location: Pf3D7_11_v3:1,201,675..1,204,113(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	expressed	0.15	0.90
Schizont	possibly expressed	0.05	0.96
Gametocyte	expressed	0.32	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1131300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.136 | MFS: -2.819 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0916900)

Modification: Disrupted | RMgm-2560

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II51

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532868

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	27	13	33
disruptive	30	85	48	105
missense	21	66	39	81

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	52	15	41
disruptive	60	154	91	161
missense	38	111	68	110

PlasmoDB Total SNPs: 102

Non-coding: 30 | Synonymous: 46 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 565 | Molecular Weight (kDa): 67.998

UniProt ID(s): Q8II51

PDB ID(s): None

Isoelectric Point: 9.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A