About Gene List

PF3D7_1131400

Genome location: Pf3D7_11_v3:1,204,242..1,210,151(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.05 0.98
Trophozoite expressed 0.36 0.79
Schizont possibly expressed 0.04 0.98
Gametocyte expressed 0.89 0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1131400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 4 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -2.973 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II50

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532670

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 14 64 50 102
disruptive 70 234 124 325
missense 49 202 113 274

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 143 77 120
disruptive 137 500 230 448
missense 78 404 187 332

PlasmoDB Total SNPs: 309

Non-coding: 123 | Synonymous: 110 | Nonsynonymous: 75 | Stop Codon: 1

Protein Information

Protein Length: 1701 | Molecular Weight (kDa): 206.85

UniProt ID(s): Q8II50

PDB ID(s): None

Isoelectric Point: 9.67

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094