PF3D7_1131500

Genome location: Pf3D7_11_v3:1,210,686..1,211,456(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.42	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1131500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.202 | MFS: -2.568 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0916700)

Relative Growth Rate: 1.02 ± 0.13
Confidence: 5.41

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0916700)

Modification: Disrupted | RMgm-2559

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II49

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532420

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	12	8	20
disruptive	8	19	13	46
missense	8	19	13	42

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	33	17	18
disruptive	10	52	33	75
missense	10	47	29	66

PlasmoDB Total SNPs: 15

Non-coding: 0 | Synonymous: 10 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 256 | Molecular Weight (kDa): 29.623

UniProt ID(s): Q8II49

PDB ID(s): None

Isoelectric Point: 6.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A