PF3D7_1131600

Genome location: Pf3D7_11_v3:1,216,521..1,224,812(+)

Genome classification: Core

Function and Localization

Product Description: kelch domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.20	0.89
Schizont	not expressed	0.04	0.98
Gametocyte	not expressed	0.74	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1131600

Resistome Missense Mutations: A1176V

Resistome Compounds with Missense Mutations: PS-3

Resistome # Samples with Disruptive Mutations: 3 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.414 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532623

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	33	122	71	137
disruptive	93	394	203	568
missense	56	313	171	466

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	55	233	120	162
disruptive	197	895	393	911
missense	111	674	316	557

PlasmoDB Total SNPs: 338

Non-coding: 0 | Synonymous: 184 | Nonsynonymous: 152 | Stop Codon: 2

Protein Information

Protein Length: 2763 | Molecular Weight (kDa): 330.303

UniProt ID(s): Q8II48

PDB ID(s): None

Isoelectric Point: 6.61

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR015915	Kelch-type beta propeller
PFam	PF13418	N/A
Superfamily	SSF117281	Kelch-type beta propeller