Product Description: oxysterol-binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0043231 | intracellular membrane-bounded organelle |
| Component | GO:0016020 | membrane |
| Function | GO:0008289 | lipid binding |
| Function | GO:0032934 | sterol binding |
| Function | GO:0015248 | sterol transporter activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.39 | 0.84 |
| Trophozoite | expressed | 0.71 | 0.61 |
| Schizont | expressed | 0.51 | 0.74 |
| Gametocyte | expressed | 0.60 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1131800
Resistome Missense Mutations: N704S
Resistome Compounds with Missense Mutations: BCH070
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.001 | #Insertions: 7
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0916600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0916600)
Modification: Disrupted | RMgm-2558
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II47
"Best" AlphaFill ligand hit: 2Y5 ((2r)-1-{[(r)-hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5z,8z,11z,14z)-icosa-5,8,11,14-tetraenoate, Local RMSD=0.32) with 4PH7 (Global RMSD=3.24)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101373
Most Similar Human Ortholog: C9J7J0
TM-align score: 0.68 | RMSD: 0.98
Seq Identity: 0.00 | Length: 25 / 1576
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000110048 | oxysterol binding protein |
| ENSG00000184792 | oxysterol binding protein 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 68 | 41 | 93 |
| disruptive | 110 | 223 | 126 | 278 |
| missense | 48 | 148 | 96 | 198 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 30 | 120 | 70 | 114 |
| disruptive | 163 | 420 | 195 | 395 |
| missense | 78 | 286 | 143 | 258 |
PlasmoDB Total SNPs: 355
Non-coding: 124 | Synonymous: 123 | Nonsynonymous: 108 | Stop Codon: 0
Protein Length: 1576 | Molecular Weight (kDa): 184.693
UniProt ID(s): Q8II47
PDB ID(s): None
Isoelectric Point: 6.16
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000648 | Oxysterol-binding protein |
| InterPro | IPR001849 | Pleckstrin homology domain |
| InterPro | IPR037239 | Oxysterol-binding protein superfamily |
| PFam | PF00169 | Pleckstrin homology domain |
| PFam | PF01237 | Oxysterol-binding protein |
| Superfamily | SSF144000 | Oxysterol-binding protein superfamily |
| Superfamily | SSF50729 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |