About Gene List

PF3D7_1131900

Genome location: Pf3D7_11_v3:1,234,061..1,236,391(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.04 0.98
Trophozoite possibly expressed 0.10 0.95
Schizont possibly expressed 0.06 0.97
Gametocyte possibly expressed 0.18 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1131900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.151 | MFS: -2.791 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0916500)

  • Relative Growth Rate: 0.98 ± 0.16
  • Confidence: 5.06

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0916500)

Modification: Disrupted | RMgm-2557

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II46

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=24.44) with 4CJ8 (Global RMSD=28.71)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127377

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 25 28 49
disruptive 31 68 34 96
missense 23 53 32 77

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 74 44 47
disruptive 58 171 88 236
missense 29 134 62 146

PlasmoDB Total SNPs: 105

Non-coding: 0 | Synonymous: 57 | Nonsynonymous: 46 | Stop Codon: 2

Protein Information

Protein Length: 776 | Molecular Weight (kDa): 93.712

UniProt ID(s): Q8II46

PDB ID(s): None

Isoelectric Point: 10.14

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094