PF3D7_1132100

Genome location: Pf3D7_11_v3:1,243,226..1,246,618(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.03	0.98
Schizont	possibly expressed	0.02	0.99
Gametocyte	possibly expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1132100

Resistome Missense Mutations: D647Y

Resistome Compounds with Missense Mutations: Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 4 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.641 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II44

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_159038

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	46	32	71
disruptive	43	173	109	220
missense	37	157	103	202

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	108	57	99
disruptive	84	367	190	373
missense	65	314	166	262

PlasmoDB Total SNPs: 97

Non-coding: 0 | Synonymous: 47 | Nonsynonymous: 49 | Stop Codon: 1

Protein Information

Protein Length: 1130 | Molecular Weight (kDa): 133.408

UniProt ID(s): Q8II44

PDB ID(s): None

Isoelectric Point: 4.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR035979	RNA-binding domain superfamily
PFam	PF00076	RNA recognition motif domain
Superfamily	SSF54928	RNA-binding domain superfamily