Genome location: Pf3D7_11_v3:1,248,292..1,251,089(-)
Genome classification: Core
Product Description: T-complex protein 1 subunit alpha
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005832 | chaperonin-containing T-complex |
| Component | GO:0005829 | cytosol |
| Component | GO:0005622 | intracellular |
| Component | GO:0005634 | nucleus |
| Function | GO:0005524 | ATP binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0006457 | protein folding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.70 | 0.68 |
| Trophozoite | expressed | 1.12 | 0.45 |
| Schizont | expressed | 0.14 | 0.92 |
| Gametocyte | expressed | 0.76 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1132200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.174 | MFS: -2.998 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_0917700)
Modification: Tagged | RMgm-1563
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II43
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.64) with 1Q3Q (Global RMSD=3.14)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101890
Most Similar Human Ortholog: F5H676
TM-align score: 0.99 | RMSD: 0.34
Seq Identity: 0.70 | Length: 111 / 544
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000120438 | t-complex 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 36 | 24 | 50 |
| disruptive | 2 | 10 | 12 | 39 |
| missense | 2 | 9 | 12 | 33 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 99 | 24 | 29 |
| disruptive | 4 | 41 | 32 | 111 |
| missense | 4 | 33 | 24 | 81 |
PlasmoDB Total SNPs: 85
Non-coding: 71 | Synonymous: 8 | Nonsynonymous: 5 | Stop Codon: 1
Protein Length: 544 | Molecular Weight (kDa): 60.261
UniProt ID(s): Q8II43
PDB ID(s): None
Isoelectric Point: 7.02
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002194 | Chaperonin TCP-1, conserved site |
| InterPro | IPR002423 | Chaperonin Cpn60/TCP-1 family |
| InterPro | IPR012715 | T-complex protein 1, alpha subunit |
| InterPro | IPR017998 | Chaperone tailless complex polypeptide 1 (TCP-1) |
| InterPro | IPR027409 | GroEL-like apical domain superfamily |
| InterPro | IPR027410 | TCP-1-like chaperonin intermediate domain superfamily |
| InterPro | IPR027413 | GroEL-like equatorial domain superfamily |
| PFam | PF00118 | Chaperonin Cpn60/TCP-1 family |
| Superfamily | SSF48592 | GroEL-like equatorial domain superfamily |
| Superfamily | SSF52029 | GroEL-like apical domain superfamily |
| Superfamily | SSF54849 | TCP-1-like chaperonin intermediate domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 25615740 | New Export Pathway in Plasmodium falciparum-Infected Erythrocytes: Role of theParasite Group II Chaperonin, PfTRiC. | Mbengue A, Vialla E, ..., Braun-Breton C | 10.1111/tra.12266 |
| 27503796 | Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. | Siau A, Huang X, ..., Preiser PR | 10.1038/srep31055 |
| 28067475 | The chaperonin T RiC forms an oligomeric complex in the malaria parasite cytosol | Spillman NJ, Beck JR, ..., Goldberg DE | 10.1111/cmi.12719 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |