About Gene List

PF3D7_1132400

Genome location: Pf3D7_11_v3:1,254,662..1,260,426(-)

Genome classification: Core

Function and Localization

Product Description: transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.23 0.89
Trophozoite expressed 1.33 0.38
Schizont expressed 0.80 0.60
Gametocyte expressed 1.27 0.39

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1132400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 7 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.766 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_0916000)

Modification: Disrupted | RMgm-4358

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II41

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532367

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 51 26 69
disruptive 77 232 119 273
missense 36 178 99 210

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 17 102 57 92
disruptive 163 482 227 396
missense 71 358 164 248

PlasmoDB Total SNPs: 402

Non-coding: 132 | Synonymous: 146 | Nonsynonymous: 123 | Stop Codon: 1

Protein Information

Protein Length: 1461 | Molecular Weight (kDa): 173.825

UniProt ID(s): Q8II41

PDB ID(s): None

Isoelectric Point: 9.43

Protein Domain Annotations:

Source Family ID Description
InterPro IPR009262 Solute carrier family 35 member SLC35F1/F2/F6
PFam PF06027 Solute carrier family 35 member SLC35F1/F2/F6
Superfamily SSF103481 N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097