PF3D7_1132500

Genome location: Pf3D7_11_v3:1,261,759..1,266,078(+)

Genome classification: Core

Function and Localization

Product Description: amino acid transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 15

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1132500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.049 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0917400)

Modification: Disrupted | RMgm-4771

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II40

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171430

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 115

Non-coding: 0 | Synonymous: 63 | Nonsynonymous: 52 | Stop Codon: 0

Protein Information

Protein Length: 1439 | Molecular Weight (kDa): 174.052

UniProt ID(s): Q8II40

PDB ID(s): None

Isoelectric Point: 9.64

Protein Domain Annotations: