Genome location: Pf3D7_11_v3:1,265,900..1,267,995(-)
Genome classification: Core
Product Description: pre-mRNA-splicing factor 38A, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071011 | precatalytic spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.63 | 0.70 |
| Trophozoite | expressed | 0.71 | 0.60 |
| Schizont | expressed | 0.33 | 0.79 |
| Gametocyte | expressed | 0.48 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1132600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.832 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II38
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102388
Most Similar Human Ortholog: Q8NAV1
TM-align score: 0.60 | RMSD: 2.51
Seq Identity: 0.49 | Length: 201 / 386
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000134748 | pre-mRNA processing factor 38A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 16 | 10 | 27 |
| disruptive | 6 | 51 | 19 | 71 |
| missense | 6 | 46 | 18 | 65 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 25 | 23 | 27 |
| disruptive | 19 | 108 | 45 | 93 |
| missense | 11 | 96 | 40 | 68 |
PlasmoDB Total SNPs: 106
Non-coding: 75 | Synonymous: 18 | Nonsynonymous: 11 | Stop Codon: 2
Protein Length: 386 | Molecular Weight (kDa): 46.656
UniProt ID(s): Q8II38
PDB ID(s): None
Isoelectric Point: 10.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005037 | Pre-mRNA-splicing factor 38 |
| PFam | PF03371 | Pre-mRNA-splicing factor 38 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 21614000 | Role of the ubiquitin-like protein Hub1 in splice-site usage and alternativesplicing. | Mishra SK, Ammon T, ..., Jentsch S | 10.1038/nature10143 |