Genome location: Pf3D7_11_v3:1,268,410..1,270,016(+)
Genome classification: Core
Product Description: 50S ribosomal protein L2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0032543 | mitochondrial translation |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.05 | 0.96 |
| Schizont | expressed | 0.02 | 0.98 |
| Gametocyte | expressed | 0.09 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1132700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.371 | MFS: -2.291 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8II37
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100234
Most Similar Human Ortholog: A0A669KAX9
TM-align score: 0.79 | RMSD: 1.81
Seq Identity: 0.35 | Length: 200 / 333
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000112651 | mitochondrial ribosomal protein L2 |
| ENSG00000161016 | ribosomal protein L8 |
| ENSG00000288564 | novel protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 17 | 15 | 20 |
| disruptive | 2 | 19 | 9 | 44 |
| missense | 2 | 19 | 7 | 42 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 43 | 15 | 27 |
| disruptive | 7 | 34 | 29 | 91 |
| missense | 4 | 27 | 27 | 61 |
PlasmoDB Total SNPs: 66
Non-coding: 56 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 333 | Molecular Weight (kDa): 37.805
UniProt ID(s): Q8II37
PDB ID(s): None
Isoelectric Point: 11.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002171 | Ribosomal protein L2 |
| InterPro | IPR005880 | Ribosomal protein L2, bacterial/organellar-type |
| InterPro | IPR008991 | Translation protein SH3-like domain superfamily |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| InterPro | IPR022666 | Ribosomal Proteins L2, RNA binding domain |
| InterPro | IPR022669 | Ribosomal protein L2, C-terminal |
| PFam | PF00181 | Ribosomal Proteins L2, RNA binding domain |
| PFam | PF03947 | Ribosomal protein L2, C-terminal |
| Superfamily | SSF50104 | Translation protein SH3-like domain superfamily |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |