About Gene List

PF3D7_1133100

Genome location: Pf3D7_11_v3:1,276,697..1,281,158(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 1.37 0.42
Trophozoite not expressed 0.81 0.58
Schizont not expressed 0.28 0.83
Gametocyte not expressed 0.62 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1133100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -2.945 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0915300)

  • Relative Growth Rate: 0.07 ± 0.09
  • Confidence: 6.21

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8II33

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532569

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 43 27 42
disruptive 31 122 74 184
missense 20 105 60 158

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 17 80 34 51
disruptive 57 251 111 230
missense 31 209 102 164

PlasmoDB Total SNPs: 222

Non-coding: 134 | Synonymous: 50 | Nonsynonymous: 38 | Stop Codon: 0

Protein Information

Protein Length: 1057 | Molecular Weight (kDa): 127.351

UniProt ID(s): Q8II33

PDB ID(s): None

Isoelectric Point: 7.18

Protein Domain Annotations:

Source Family ID Description
InterPro IPR026704 Katanin-interacting protein
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104